Making Better Drugs for Children with Cancer

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Making Better Drugs for Children with Cancer

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Glioblastoma Treatment with 2,5-Dimethyl-Celecoxib (DMC) In Vitro: Effects of Additional Chemotherapeutic Drugs and Tumor Microenvironment – … Used In Vitro Cell Growth and Survival Assays

Saturday, February 5th, 2011 at 8:48 pm

Glioblastoma Treatment with 2,5-Dimethyl-Celecoxib (DMC) In Vitro: Effects of Additional Chemotherapeutic Drugs and Tumor Microenvironment - ... Used In Vitro Cell Growth and Survival Assays

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2,5-dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex®) that lacks COX-2 inhibitory function yet maintains all of celecoxibs anti-tumor properties. We set out to investigate the potential of combining current glioblastoma chemotherapies with DMC as a new approach to enhance glioblastoma cell killing. DMC was not only able to enhance tumor cell killing when combined with other drugs but also induced glioblastoma growth arrest and apoptosis in low glucose and hypoxic conditions which are normally associated with chemoresistance. Therefore, if DMC were used in combination it may potentially be able to reverse this... [Read More]

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$139.99

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$75.09

5 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

$142.90

10 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a dru... [Read more]

$91.12

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Drug Treatment: What Works?

Saturday, February 5th, 2011 at 8:46 pm

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Britain, like almost everywhere else, has a burgeoning drug problem. Finding ways of dealing with this problem is a major platform of government policy and a great deal has been made of the impact of treatment on drug users. Drug Treatment: What Works? is a cutting edge survey of the latest developments in these treatments, and it sets out to ask some of the crucial questions in the treatment of drug abusers; including:* Which treatments work with what sorts of abusers?* What are the key indicators of likely success?* Does coercion work or must treatment be freely entered into? *... [Read More]

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$142.90

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Substance Use and Misuse: Nature, Context and Clinical Interventions

Saturday, February 5th, 2011 at 8:46 pm

Substance Use and Misuse: Nature, Context and Clinical Interventions

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Substance Use and Misuse is a comprehensive and practical text that covers the core elements of substance use and misuse in both acute and community settings. The text reflects those areas in which health-care professionals are assuming greater responsibility for those people misusing psychoactive substances. It adopts a skills-orientated approach, providing a framework of good clinical practice and is written by a group of clinicians and academics. This book is an invaluable tool for undergraduate and postgraduate students, educators and clinical practitioners in all branches of nursing, midwifery and health visiting. It is also relevant to others in the healing... [Read More]

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Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development)

Saturday, February 5th, 2011 at 8:46 pm

Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development)

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Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

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Parkinson’s Disease Treatment Guide for Physicians

Saturday, February 5th, 2011 at 8:43 pm

Parkinson's Disease Treatment Guide for Physicians

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Roughly 1.9 million people are afflicted with Parkinson's disease and, according to the Parkinson's Disease Foundation, that number is on the rise! Parkinson's Disease Treatment Guide for Physicians will comprehensively cover Parkinson's disease (PD), including diagnosis, testing, prognosis, and possible causes. Its primary focus will be on treatment, specifying appropriate drugs, doses, and common side effects. It will address not only the treatment of motor problems (tremor, gait, etc.), but everything else that routinely arises in a PD practice, including osteoporosis prevention, blood pressure, sexual, bowel, or bladder dysfunction, dementia, depression, common skin rashes, and more. This book... [Read More]

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HIV-1 Resistance in Supervised Treatment Settings: Predictors and Consequences of Drug Resistance inPatients with Late Stage Human ImmunodeficiencyVirus -1 disease in Supervised Treatment Settings

Saturday, February 5th, 2011 at 8:42 pm

HIV-1 Resistance in Supervised Treatment Settings: Predictors and Consequences of Drug Resistance inPatients with Late Stage Human ImmunodeficiencyVirus -1 disease in Supervised Treatment Settings

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Positive treatment outcomes for patients with HumanImmunodeficiency Virus-1 (HIV-1) disease may becompromised by the selection of HIV-1 drug resistantmutants (HIVDRM), particularly in marginalizedpopulations where fragmented care is prevalent.Adherence as an important co-factor in selectingHIVDRMs has been controversial. Thus, understandingthe causes and effects of HIVDRMs in the contextadherence is provocative. In this monograph, wesynthesize the literature on antiretroviralresistance testing and discuss its use as a publichealth tool. We conducted an investigation of theresistance testing effects on treatment outcomesamong patients with late stage HIV-1 disease insupervised treatment settings in NYC. The genotypicsensitivity score (GSS), a summary measure of regimenpotency in the context... [Read More]

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$142.90

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Treating Chemically Dependent Families: A Practical Systems Approach for Professionals (Professional Series)

Saturday, February 5th, 2011 at 8:41 pm

Treating Chemically Dependent Families: A Practical Systems Approach for Professionals (Professional Series)

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What we know about chemical dependence and families doesn't help--what does help is what we do with what we know. Our knowledge and opinions are of no value until we translate them into clinical actions the family can hear, see, and feel. Techniques and strategies are the vehicles for this translation; they bring our concepts, theories, and hunches to bear on face-to-face encounters with families, where they can do some good. Here is a book for any helping professional who works with families suffering from the effects of chemical dependence. Dr. Edwards is keenly aware that family is where... [Read More]

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Integrated Treatment for Mood and Substance Use Disorders

Saturday, February 5th, 2011 at 8:40 pm

Integrated Treatment for Mood and Substance Use Disorders

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List Price: $45.00

Sale Price: $23.82

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People with mood disorders often have simultaneous problems with addiction, and those with substance abuse problems are especially susceptible to mood disorder. The treatment of such patients can be particularly complicated, and many receive treatment for only one of their disorders. In this book, fourteen clinicians discuss the extent of the problem, methods of assessment, typical courses, and treatments—including both psychotherapy and pharmacotherapy. They address the all-too-frequent necessity of proceeding with treatment before a clear diagnosis is known, and they claim that distinguishing between primary and secondary disorders is initially less critical than previously assumed. Contending that clinicians treating comorbid... [Read More]

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Addiction and Pregnancy: Empowering Recovery through Peer Counseling

Saturday, February 5th, 2011 at 8:39 pm

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Total Customer Reviews: (0)

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$74.48

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Imaging in CNS Drug Discovery and Development: Implications for Disease and Therapy

Saturday, February 5th, 2011 at 8:34 pm

Imaging in CNS Drug Discovery and Development: Implications for Disease and Therapy

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Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease... [Read More]

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Drug Court Justice (New Perspectives in Criminology and Criminal Justice)

Saturday, February 5th, 2011 at 8:33 pm

Drug Court Justice (New Perspectives in Criminology and Criminal Justice)

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This book is an exploratory study of a juvenile drug treatment court in the Midwest. Based on observations and interviews the author conducted while serving as the contracted program evaluator, the book investigates how denial, surveillance, coercion, accountability, and definitions of success operate and interact in the Juvenile Drug Court environment and intertwine with institutional needs and authority structures. The book's findings suggest that some drug court practices may expose participants to potential harms that until now have been largely ignored in studies of drug courts. Drug Court Justice concludes with suggestions for reducing the potential harms of juvenile drug... [Read More]

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Alcoholism: Its Treatments and Mistreatments

Saturday, February 5th, 2011 at 8:33 pm

Alcoholism: Its Treatments and Mistreatments

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This important book provides a review of the Minnesota Model of alcoholism treatment, which combines current clinical treatments and the 12-step principles of Alcoholics Anonymous with the goal of abstinence. It critically examines the research base supporting cognitive behavior therapy approaches to alcoholism. Using evidence from biosociobehavioral science and critical analyses of alcoholism treatment outcome literature, the book rebuts the view of cognitive behavior therapists that alcoholism is nothing but a bad habit . This book fills a vital need, describing which alcoholism treatments work and which do not. It is an invaluable guide to the helping professions caring... [Read More]

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Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings (A WPRO Publication)

Saturday, February 5th, 2011 at 8:31 pm

Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings (A WPRO Publication)

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These WHO guidelines are designed to assist staff of closed settings to provide safe and effective withdrawal management and treatment services for people who use drugs in the Western Pacific Region. It provides information about drugs and drug dependence; the management of drug withdrawal; and approaches to treatment for drug dependence. For the purposes of this document, "closed settings" refers to prisons, work camps, compulsory drug treatment centers and any other institution in which people are detained.The Guidelines take a public health approach to drug use and dependence. This approach recognizes that the health of one individual affects the health... [Read More]

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CURRENT Diagnosis & Treatment in Neurology (LANGE CURRENT Series)

Saturday, February 5th, 2011 at 8:24 pm

CURRENT Diagnosis & Treatment in Neurology (LANGE CURRENT Series)

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List Price: $79.00

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Neurology Joins the Lange CURRENT Series!

Authored by renowned authorities in the field, CURRENT Diagnosis & Treatment in Neurology provides a reliable, current, and ready reference for primary care physicians managing patients with neurologic disorders.

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions

Saturday, February 5th, 2011 at 8:23 pm

New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions

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New and improved therapies to treat and protect against drug dependence and abuse are urgently needed. In the United States alone about 50 million people regularly smoke tobacco and another 5 million are addicted to other drugs. In a given year, millions of these individuals attempt and with or without medical assistance and to quit using drugs, though relapse remains the norm. Furthermore, each year several million teenagers start smoking and nearly as many take illicit drugs for the first time. Research is advancing on promising new means of treating drug addiction using immunotherapies and sustained-release (depot) medications.The aim of... [Read More]

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Aromatase Inhibitors (Milestones in Drug Therapy)

Saturday, February 5th, 2011 at 8:20 pm

Aromatase Inhibitors (Milestones in Drug Therapy)

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This book provides the first comprehensive overview on the different aromatase inhibitors. Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not very potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency.

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Cannabis Therapeutics in HIV/Aids (Journal of Cannabis Therapeutics, V. 1, No. 3/4)

Saturday, February 5th, 2011 at 8:18 pm

Cannabis Therapeutics in HIV/Aids (Journal of Cannabis Therapeutics, V. 1, No. 3/4)

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Explore the controversial subject of cannabis therapeutics for HIV/AIDS patients!Cannabis Therapeutics in HIV/AIDS provides a scientific view of the benefits of marijuana in helping to increase appetite, ease the symptoms of HIV/AIDS, and improve quality of life for patients. Dr. Ethan Russo, editor of the Journal of Cannabis Therapeutics, has assembled a collection of first-rate information from clinicians, researchers, and patients. Based on scientific research, this book offers insights into how using cannabis has helped patients deal with the symptoms of HIV/AIDS. This informative book contains: a broad medical overview of the pertinent topics of interest with respect toAIDS... [Read More]

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Drugs and Addictive Behaviour: A Guide to Treatment

Saturday, February 5th, 2011 at 8:18 pm

Drugs and Addictive Behaviour: A Guide to Treatment

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This completely revised and updated third edition presents a comprehensive overview of substance misuse and dependence. The volume places a special emphasis on practical, evidence-based approaches to the assessment and management of a wide range of drug-related problems in a variety of clinical settings, and includes an entirely new chapter on alcohol abuse. The author defines all the terms and describes the effects of substance misuse on a patient's life. Epidemiology, and international prevention and drug control policies are covered to address the global nature of the problem, and the appendix provides a series of clinical intervention tools, among them... [Read More]

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Alternative and Complementary Therapies for Cancer: Integrative Approaches and Discovery of Conventional Drugs

Saturday, February 5th, 2011 at 8:12 pm

Alternative and Complementary Therapies for Cancer: Integrative Approaches and Discovery of Conventional Drugs

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Cancer is a common disease with a devastating impact on the physical and psychological well being of patients. The diagnosis of cancer brings upon many clinical challenges and questions for which clear and simple answers are not always provided by modern medicine. To date, only limited therapeutic options are available for patients with advanced cancer. The recent shift toward targeted therapies has improved substantially patient’s survival, however, relapses are frequent and cure remains rare. This led patients and many health care managers to shift attention to the holistic approach of traditional medicine particularly preparations from herbal products to manage and... [Read More]

$74.48

5 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

$14.99

Wall Adapter Q3I-Acc-100 [Read more]

$39.88

2 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

AlcoHAWK Precision Elite Pt500 Mouthpieces 50 Pk Q3I-Acc-3050

$19.99

Slim Mouthpieces 50 Pk Q3I-Acc-2550 [Read more]

$19.99

Precision Elite Pt500 Mouthpieces 50 Pk Q3I-Acc-3050 [Read more]

$7.99

Slim Mouthpieces 10 Pk Q3I-Acc-2510 [Read more]

$78.40

5 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

$139.99

10 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a dru... [Read more]

$62.50

4 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

$60.50

4 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

$75.09

5 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]

$142.90

10 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a dru... [Read more]

$91.12

6 Test Urine Panel The Rapid Response Urine Test Panel is a one-step rapid dip test. It is simple to administer and results are visible within minutes. Positives for a drug... [Read more]